How a partnership saved millions of children’s lives with vaccines

More than one billion children in lower-income countries have been protected with life-saving vaccines since 2000, thanks in part to a global partnership called Gavi, the Vaccine Alliance.

How did it happen?

Nakanyike Annet waits with her baby Natasha Kwagala, 3 months, for immunizations at the Nakaseke General Hospital in Nakaseke District, Uganda, on September 8, 2023.
Nakanyike Annet waits with her baby, Natasha, for immunizations at the Nakaseke General Hospital in Uganda. ©Gates Archive/Zahara Abdul
Understanding the impact
1.1B
children immunized due to Gavi efforts

In 2000, millions of children in lower-income countries were dying each year from diseases that were preventable with vaccines. To address this disparity, a multi-sectoral effort was launched—a partnership of countries, agencies like WHO, UNICEF and the World Bank, the private sector, civil society, and the Gates Foundation—with the shared goal of saving lives and protecting people’s health by increasing access to vaccines. This partnership became Gavi, the Vaccine Alliance.

Since then, Gavi has become one of the most successful development initiatives in history.

A testament to the power of partnership in building a healthier, more equitable future for all, learn more about Gavi’s work and the impact the alliance has had over the past 25 years:

 

2000
A new era for global immunization begins

Gavi, the Vaccine Alliance launches as a public-private partnership with a mission to ensure life-saving vaccinations reach children in lower-income countries.

The Gates Foundation pledges $750 million to support Gavi for its first five years.

Gavi logo
2001
Gavi support available in 74 eligible countries

Gavi’s vaccine portfolio launches with vaccines protecting against six diseases – hepatitis B, diphtheria, tetanus, pertussis (whooping cough), Haemophilus influenzae type b and yellow fever.

Gavi’s ambition accelerates a process that could have taken decades for new vaccines to reach people around the world.

A view of a pentavalent vaccine preparation at Umoja Heath Centre in Nairobi on May 16, 2019.
2003
Growing support and impact for Gavi

Five-year commitments from donors top $1 billion providing crucial funds to continue vaccinating the world’s poorest children.

By this time, Gavi has helped immunize 30 million children against hepatitis B, 4.3 million children against Haemophilus influenzae type b, and 1.6 million children against yellow fever.

Gavi has also reached 8.3 million children with basic childhood vaccines who would otherwise have not been reached with any vaccines at all.

2006
IFFim: An innovative approach to finance immunization

Gavi launches the use of vaccine bonds to convert long-term donor pledges into immediate funding for Gavi programs.

It’s called the International Finance Facility for Immunization. It’s the first mechanism of its kind.

2007
Expanding protection against measles

Gavi begins supporting an important second dose of measles vaccine for countries that already introduced a first dose.

Measles is one of the deadliest and most contagious infectious diseases – and also one of the most easily preventable.

In 2013, this support will expand to include two doses of the combined measles-rubella vaccine.

By the end of 2023, more than 214 million children will be reached with measles-containing vaccines.

2008
A vaccine to prevent diarrheal disease

The first doses of Gavi-supported rotavirus vaccine are purchased and introduced into routine immunization systems.

The rotavirus vaccine prevents the deadliest form of diarrheal disease in young children.

2009
A new financing plan for pneumonia vaccines

A new financing mechanism launches to accelerate the global rollout of the pneumococcal conjugate vaccine (PCV) to protect against pneumonia, the leading infectious cause of death in children.

Launched by Gavi, the Pneumococcal Vaccine Advance Market Commitment will incentivize the creation of new, more affordable PCVs and accelerate introductions in 60 Gavi-eligible lower-income countries.

2010
A game-changing meningitis vaccine

The first Meningitis A vaccine – MenAfriVac – becomes available for countries as part of Gavi’s portfolio.

Over the next ten years, 360 million people across sub-Saharan Africa will be immunized.

2012
A revolutionary vaccine to prevent cervical cancer

Human papillomavirus (HPV) vaccines become available for countries as part of Gavi’s portfolio.

From 2014 to 2023, 27.2 million girls will be fully immunized, which means more than 600,000 cervical cancer deaths averted.

2013
Gavi supports global efforts to end polio

The Inactivated Polio Vaccine (IPV) becomes available for countries with support from Gavi.

By May of 2019, all Gavi supported countries will successfully introduce IPV into their national immunization programs.

2014
Vaccine stockpiles: A new strategy to prevent stockouts

Gavi begins funding the Global Oral Cholera Vaccine (OCV) Stockpile to support emergency response, humanitarian crises and preventive vaccination in countries with endemic cholera.

By July of 2024, the stockpile will enable the delivery of 200 million doses to help communities prevent stockouts and mitigate severe outbreaks.

2016
New partnerships bring drones to vaccine delivery

The Government of Rwanda partners with technology company Zipline, Gavi, and others to explore the potential of delivering health products by autonomous drone.

By 2024, a handful of lower-income countries will use drones to overcome challenges in delivering vaccines and other medical supplies to hard-to-reach places.

2019
A new vaccine to prevent childhood typhoid

The typhoid conjugate vaccine (TCV) becomes available for countries as part of Gavi’s portfolio. It’s the first preventative tool providing longer term protection against typhoid in children as young as six months – one of the groups most vulnerable to typhoid.

TCVs also reduce the need for antibiotics, helping to prevent drug-resistant strains of typhoid from emerging and spreading.

2020
Gavi organizes a global response to the COVID-19 pandemic

Gavi launches the COVAX Advance Market Commitment (AMC) to help ensure COVID-19 vaccines and technical support are available for lower-income countries.

COVAX will deliver nearly 1.9 billion doses of COVID-19 vaccines to 146 countries.

2022
Gavi increases support for the HPV vaccine

Gavi revitalizes the HPV vaccine program with a US$600 million investment to support additional countries that introduce this cancer-preventing vaccine.

With more funding and assistance available for HPV vaccination programs, and support for countries switching to a one-dose HPV vaccine schedule, Gavi aims to reach over 86 million girls with the HPV vaccine by 2025 and potentially avert 1.4 million future deaths from cervical cancer.

2023
A new initiative to support African vaccine manufacturing

Gavi approves the African Vaccine Manufacturing Accelerator (AVMA) to help catalyze the sustainable growth of vaccine manufacturing in Africa.

A worker places syringes in the package molds at the Revital Healthcare factory in Kikambala, Kenya, on July, 10, 2024.Revital Healthcare became the first East and Central African company to manufacture medical devices such as auto-disabled syringes and reuse-preventing syringes and has grown to become one of the largest manufacturers of medical disposable products in Africa.
2024
The world’s first malaria vaccines

The first-ever malaria vaccines, RTS,S/AS01 and R21/Matrix-M, are made available for children through the national immunization programs of eligible African countries with Gavi support.

Alongside other critical interventions, these first-generation malaria vaccines can help save thousands more children from this preventable disease.

With continued support for Gavi and partners, we can protect more children against more diseases, faster than ever before.

Learn more about Gavi’s work today and what’s needed to ensure it continues.

It is unjust for a child to be denied access to vaccines because of where they are born or whether their family can pay.
Dr. Sania Nishtar
CEO
Gavi

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