South Africa

We work with the South African government and other partners to apply the country’s global influence, research expertise, and health and development innovations to address the population’s greatest needs in health, agriculture, and water, sanitation, and hygiene.
Students in front of toilets at a primary school outside Durban, South Africa.

At a glance

  • Since making our first grants in South Africa in 1999, we have been committed to addressing issues such as the country’s high rates of HIV and tuberculosis (TB), social inequality, and inadequate water and sanitation infrastructure.
  • South Africa has less than 1 percent of the world’s population, but it accounts for 18 percent of the world’s HIV infections and HIV-related deaths and 6 percent of the world’s TB infections and 2.5 percent of global TB-related deaths.
  • South Africa’s future depends on the country’s ability to apply its scientific expertise and other resources to address challenges in health, social inequality, and lack of opportunity for the growing youth population.

The latest updates on our work in South Africa

Professor Valerie Mizrahi, Senior Scholar, Molecular Biology, University of Cape Town, Mark Suzman, CEO, Gates Foundation, Dr Akhona Vava, International Centre for Genetic Engineering and Biotechnology and Kelly Chibale, Professor of organic Chemistry, University of Cape Town pose for a photograph after of a Roundtable conversation in Cape Town, South Africa, February 26, 2025.

Advancing health: A journey through science and innovation

This three-part conversation features three distinguished scientists—Professor Kelly Chibale, Dr Vava, and Professor Valerie Mizrahi—exploring how science and innovation drive global health progress.
Nandipha Titana

A trusted voice in the fight against TB

Nandipha Titana helps fight TB in her South African community by connecting people to care and building trust through her work at Be Part.
Better Toilets, Better Students

How do better toilets lead to better attendance?

Enviro Loo, a toilet technology and water sanitation project in South Africa supported by the Bill & Melinda Gates Foundation, is helping to improve the lives of students.
Six Picks from Goalkeeper Thulile Khanyile

Six picks from scientist Thulile Khanyile

When you need to look at a problem in a new light, turn to this South African scientist’s recommendations.

Overview

South Africa is among the most prosperous, innovative countries in Africa, and its R&D sector is critical to the future of the entire continent and scientific progress globally. But the benefits of this innovation and prosperity are spread unevenly. The country’s future depends on its ability to apply these assets to address challenges in health, social inequality, and lack of opportunity for the growing youth population.

We work with the South African government and other partners to help the country make progress in the following areas:

  • Development of new drugs, diagnostics, and vaccines for HIV and TB
  • Delivery of proven HIV prevention and treatment programs
  • Delivery of TB prevention and treatment interventions
  • Technical assistance and support for programs that aim to improve family health, agriculture, and water, sanitation, and hygiene
A researcher at H3D, a drug discovery and development lab at the University of Cape Town in Cape Town, South Africa.

More about our work in Africa

Regional office

Our office in Johannesburg is the foundation's regional headquarters in Africa.

Fact sheet: Our work in Africa

A brief overview of our priorities in Africa.

Ideas

Read the latest stories, research, and news from across the foundation and subscribe to our weekly newsletter, The Optimist.